| 3.5 | Class: Tryptophan cluster factors (WC), Alignment |
| Note: The three families of this class do not share significant sequence similarities. Therefore, the sequence aligments of their DNA-binding domains will be listed separately for the Myb/SANT family (3.5.1), the Ets family (3.5.2), and the IRF family (3.5.3). | |
| Aligned Myb/SANT sequences (Family 3.5.1): | |
| Note that many factors of this family have two or three repeats of myb type, which have been separately aligned and consecutively numbered. | |
GKTRWTREEDEKLKKLVEQNG----------TDDWKVIANYLPNRTDV------------QCQHRWQ-KVLNPEL MYB(1) IKGPWTKEEDQRVIELVQKYG----------PKRWSVIAKHLKGRIGK------------QCRERWH-NHLNPEV MYB(2) KKTSWTEEEDRIIYQAHKRLG-----------NRWAEIAKLLPGRTDN------------AIKNHWN-STMRRKV MYB(3) CKVKWTHEEDEQLRALVRQFG----------QQDWKFLASHFPNRTDQ------------QCQYRWL-RVLNPDL MYBB(1) VKGPWTKEEDQKVIELVKKYG----------TKQWTLIAKHLKGRLGK------------QCRERWH-NHLNPEV MYBB(2) KKSCWTEEEDRIICEAHKVLG-----------NRWAEIAKMLPGRTDN------------AVKNHWN-STIKRKV MYBB(3) LKKLWNRVKWTRDEDDKLKKLVEQH-----GTDDWTLIASHLQNRSDF------------QCQHRWQ-KVLNPEL AMYB(1) IKGPWTKEEDQRVIELVQKYG----------PKRWSLIAKHLKGRIGK------------QCRERWH-NHLNPEV AMYB(2) KKSSWTEEEDRIIYEAHKRLG-----------NRWAEIAKLLPGRTDN------------SIKNHWN-STMRRKV AMYB(3) KGGVWRNTEDEILKAAVMKYG----------KNQWSRIASLLHRKSAK------------QCKARWY-EWLDPSI CDC5L(1) KKTEWSREEEEKLLHLAKLMP-----------TQWRTIAPII-GRTAA------------QCLEHYE-FLLDKAA CDC5L(2) NKQEWSREEEERLQAIAAAHG----------HLEWQKIAEELGTSRSA------------FQCLQKF-QQHNKAL SNAPC4(1) KKGYWAPEEDAKLLQAVAKYG----------EQDWFKIREEVPGRSDA------------QCRDRYL-RRLHFSL SNAPC4(2) KKGRWNLKEEEQLIELIEKYG----------VGHWAKIASELPHRSGS------------QCLSKWK-IMMGKKQ SNAPC4(3) FMNVWTDHEKEIFKDKFIQHP-----------KNFGLIASYLERKSVP------------DCVLYYY-LTKKNEN NCoR1(1) ETSRWTEEEMEVAKKGLVEHG-----------RNWAAIAKMVGTKSEA------------QCKNFYF-NYKRRHN NCoR1() VMNMWSEQEKETFREKFMQHP-----------KNFGLIASFLERKTVA------------ECVLYYY-LTKKNEN NCoR2(1) ESSRWTEEEMETAKKGLLEHG-----------RNWSAIARMVGSKTVS------------QCKNFYF-NYKKRQN NCoR2(2) FPDEWTVEDKVLFEQAFSFHG-----------KTFHRIQQMLPDKSIA------------SLVKFYY-SWKKTRT RCoR1(1) CNARWTTEEQLLAVQAIRKYG-----------RDFQAISDVIGNKSVV------------QVKNFFV-NYRRRFN RCoR1(2) FPDEWTVEDKVLFEQAFGFHG-----------KCFQRIQQMLPDKLIP------------SLVKYYY-SWKKTRS RCoR2(1) FNSRWTTDEQLLAVQAIRRYG-----------KDFGAIAEVIGNKTLT------------QVKTFFV-SYRRRFN RCoR2(2) INARWTTEEQLLAVQGVRKYG-----------KDFQAIADVIGNKTVG------------QVKNFFV-NYRRRFN RCoR3(1) FPDEWTVEDKVLFEQAFSFHG-----------KSFHRIQQMLPDKTIA------------SLVKYYY-SWKKTRS RCoR3(2) ELSVWTEEECRNFEQGLKAYG-----------KDFHLIQANKVRTRSVG-----------ECVAFYY-MWKKSER MIER1 GLCAWSEEECRNFEHGFRVHG-----------KNFHLIQANKVRTRSVG-----------ECVEYYY-LWKKSER MIER2 GMTAWTEEECRSFEHALMLFG-----------KDFHLIQKNKVRTRTVA-----------ECVAFYY-MWKKSER MIER3 EMEEWSASEANLFEEALEKYG-----------KDFTDIQQDFLPWKSLT-----------SIIEYYY-MWKTTDR MTA1 EMEEWSASEAMLFEEALEKYG-----------KDFNDIRQDFLPWKSLA-----------SIVQFYY-MWKTTDR MTA2 EMEEWSASEASLFEEALEKYG-----------KDFNDIRQDFLPWKSLT-----------SIIEYYY-MWKTTDR MTA3 IEKCWTEDEVKRFVKGLRQYG-----------KNFFRIRKELLPNKETG-----------ELITFYY-YWKKTPE RERE HDDAWTKAETDHLFDLSRRFD-----------LRFVVIHDRYDHQQFKK-----------RSVEDLKERYYHICA DMAP1 GSDKWTSLERKLFNKALATYS-----------KDFIFVQKMVKSKTVA------------QCVEYYY-TWKKIMR TRERF1 GSDVWTPIEKRLFKKAFYAHK-----------KDFYLIHKMIQTKTVA------------QCVEYYY-IWKKMIK ZNF541 QWESWSTEDKNTFFEGLYEHG-----------KDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITK CRAMP1L GSDQWKMAERKLFNKGIAIYK-----------KDFFLVQKLIQTKTVA------------QCVEFYY-TYKKQVK C14orf43 QAPEWTEEDLSQLTRSMVKFP------GGTPGRWEKIAHELG------------------RSVTDVT-TKAKQLK DNAJC1(1) AEEPWTQNQQKLLELALQQYP------RGSSDRWDKIARCVPS-----------------KSKEDCIARYKLLVE DNAJC1(2) GSKNWSEDDLQLLIKAVNLFP------AGTNSRWEVIANYMNI-----------------HSSSGVKRTAKDVIG DNAJC2(1) DFTPWTTEEQKLLEQALKTYP------VNTPERWEKIAEAVPG-----------------RTKKDCMKRYKELVE DNAJC2(2) GFTNWTKRDFNQFIKANEKYG----------RDDIDNIAREVEGKSPE------------EVMEYSAVFWERCNE SMARCA1(1) KGKNYTEEEDRFLICMLHKMG-----------FDRENVYEELRQCVRNAP----------QFRFDWFIKSRTAME SMARCA1(2) GFTNWNKRDFNQFIKANEKWG----------RDDIENIAREVEGKTPE------------EVIEYSAVFWERCNE SMARCA5(1) KGKNYTEEEDRFLICMLHKLG-----------FDKENVYDELRQCIRNSP----------QFRFDWFLKSRTAME SMARCA5(2) LDPSWTAQEEMALLEAVMDCG----------FGNWQDVANQMCTKTKE------------ECEKHYMKHFINNPL TADA2A AEGGWTSREEQLLLDAIEQFG----------FGNWEDMAAHVGASRTPQ-----------EVMEHYVSMYIHGNL TADA2B AGREWTEQETLLLLEALEMYK-----------DDWNKVSEHVGSRTQD------------ECILHFL-RLPIEDP SMARCC1 ATREWTEQETLLLLEALEMYK-----------DDWNKVSEHVGSRTQD------------ECILHFL-RLPIEDP SMARCC2 HVGKYTPEEIEKLKELRIKHG-----------NDWATIGAALGRSASSV-----------KDRCRLM-KDTCNT- DMTF(1) --GKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEK------------QCRSKWL-NYLNWKQ DMTF(2) GGTEWTKEDEINLILRIAELDVADENDI-----NWDLLAEGWSSVRSPQ-----------WLRSKWW-TIKRQIA DMTF(3)
| Aligned Ets sequences (Family 3.5.2): |
IQLwQFLLELLTDKSCQ-SFISwT-GDGwEFKLSD-PDE-VARRwGKRK-NKPKMNYEKLSRGLR ETS1 IQLWQFLLELLSDKSCQ-SFISWT-GDGWEFKLAD-PDE-VARRWGKRK-NKPKMNYEKLSRGLR ETS2 IQLwQFLLELLHDGARS-SCIRwT-GNSREFQLCD-PKE-VARLwGERK-RKPGMNYEKLSRGLR ETV2 IQLwQFLLELLTDKDAR-DCISwV-GDEGEFKLNQ-PEL-VAQKwGQRK-NKPTMNYEKLSRALR GABPA IQLwQFLLELLSDSANA-SCITwE-GTNGEFKMTD-PDE-VARRwGERK-SKPNMNYDKLSRALR FLI1 IQLwQFLLELLSDSSNS-SCITwE-GTNGEFKMTD-PDE-VARRwGERK-SKPNMNYDKLSRALR ERG IQLwQFLLELLADRANA-GCIAwE-GGHGEFKLTD-PDE-VARRwGERK-SKPNMNYDKLSRALR FEV IQLwHFILELLQKEEFR-HVIAwQQGEYGEFVIKD-PDE-VARLwGRRK-CKPQMNYDKLSRALR ETV3 IQLwHFILELLQKEEFR-HVIAwQQGEYGEFVIKD-PDE-VARLwGRRK-CKPQMNYDKLSRALR ETV3L IQLwHFILELLRKEEYQ-GVIAwQ-GDYGEFVIKD-PDE-VARLwGVRK-CKPQMNYDKLSRALR ERF VTLwQFLLQLLREQGNG-HIISwTSRDGGEFKLVD-AEE-VARLwGLRK-NKTNMNYDKLSRALR ELK1 ITLwQFLLQLLLDQKHE-HLICwTSND-GEFKLLK-AEE-VAKLwGLRK-NKTNMNYDKLSRALR ELK3 ITLwQFLLQLLQKPQNK-HMICwTSND-GQFKLLQ-AEE-VARLwGIRK-NKPNMNYDKLSRALR ELK4 LQLwQFLVALLDDPSNS-HFIAwTGRG-MEFKLIE-PEE-VARRwGIQK-NRPAMNYDKLSRSLR ETV1 LQLwQFLVALLDDPTNA-HFIAwTGRG-MEFKLIE-PEE-VARLwGIQK-NRPAMNYDKLSRSLR ETV4 LQLwQFLVTLLDDPANA-HFIAwTGRG-MEFKLIE-PEE-VARRwGIQK-NRPAMNYDKLSRSLR ETV5 IYLwEFLLALLQDKATCPKYIKwTQREKGIFKLVD-SK-AVSRLwGKHK-NKPDMNYETMGRALR ELF1 TYLwEFLLDLLQDKNTCPRYIKwTQREKGIFKLVD-SK-AVSKLwGKHK-NKPDMNYETMGRALR ELF2 IYLwEFLLALLQDRNTCPKYIKwTQREKGIFKLVD-SK-AVSKLwGKQK-NKPDMNYETMGRALR ELF4 THLwEFIRDILLNPDKNPGLIKwEDRSEGVFRFLKS--EAVAQLwGKKK-NNSSMTYEKLSRAMR EHF THLwEFIRDILIHPELNEGLMKwENRHEGVFKFLRS--EAVAQLwGQKKKN-SNMTYEKLSRAMR ELF3 SHLwEFVRDLLLSPEENCGILEwEDREQGIFRVVKS--EALAKMwGQRKKN-DRMTYEKLSRALR ELF5 IRLYQFLLDLLRSGDMK-DSIwwVDKDKGTFQFSSKHKEALAHRwGIQKGNRKKMTYQKMARALR SPI1 LRLyQFLLGLLTRGDMR-ECVwwVEPGAGVFQFSSKHKELLARRwGQQKGNRKRMTYQKLARALR SPIB LRLFEYLHESLYNPEMA-SCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALR SPIC RLLwDYVYQLLSDSRYEN-FIRwEDKESKIFRIVD-PNG-LARLwGNHK-NRTNMTYEKMSRALR ETV6 RLLwDYVYQLLLDTRYEP-YIKwEDKDAKIFRVVD-PNG-LARLwGNHK-NRVNMTYEKMSRALR ETV7 IHLwQFLKELLLKPHSYGRFIRwLNKEKGIFKIEDS--AQVARLwGIRK-NRPAMNYDKLSRSIR SPDEF
| Aligned IRF sequences (Family 3.5.3): |
RMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAG---------EKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLP IRF1 RMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPG---------VDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLP IRF2 KPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-DFGIFQAWAEATGAYVPG---------RDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPH-DPHKIYEFVN IRF3 NGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREG---------IDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVP IRF4 RVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEG---------VDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCS IRF5 RVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEG---------VDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCD IRF6 RVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEA-DARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGD-PADPHKVYALSR IRF7 GRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG----------DKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVP IRF8 TRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFKAWAIFKGKYKEG----------DTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLP IRF9